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12 15] 4 Case Reports/Case Series [16 19] 1 Prospective Trial [20] Dexemedetomidine does not protect against withdrawal seizures and should not be used as monotherapy Ketamine 1 Retrospective Review [21] Clinical Bottom Line Phenobarbital, propofol, and dexmedetomidine have been shown to reduce benzodiazepine requirements in AWS Nothing has proven to shorten AWS duration or ICU LOS Dexmedetomidine does not protect against withdrawal seizures and should not be used as monotherapy References: Rosenson J et al

Moreover, the less severe skeletal defects observed in the Cart igf-1r mutants compared to the global knockouts indicates that other cells such as osteoblasts (Zhang et al., 2002), osteoclasts (Wang et al., 2006a), and osteocytes (Reijnders et al., 2007), also contribute to normal skeletal development

Bohnsack, K

A single concentration may show an effect under one set of culture conditions but fail to reproduce under another