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Activation of nuclear factor-kappaB during doxorubicin-induced apoptosis in endothelial cells and myocytes is pro-apoptotic: the role of hydrogen peroxide

In particular, we focused on the p21 N-terminal cyclin-CDK binding domain, required for inhibition of G1/S cell cycle progression, and the C-terminal PCNA binding domain involved in suppressing DNA synthesis (Chen et al, 1995) (Fig 2D)

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