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Disruption of clock genes: desynchrony at the molecular level The SCN, as the master circadian clock, derives its rhythm from a transcription-translation feedback loops (TTFLs) driven by a series of clock genes (e.g., CLOCK , BMAL1 , Per , Cry ) (80)

Specifically, marked reductions in liver weights and TAG contents were observed, alongside reductions in liver biomarkers of lipid peroxidation (malondialdehyde content) and inflammation (TNF- and transforming growth factor beta, TGF- 1)

However, safety depends on several factors: The specific peptide and dose The dogs age, breed, and health status The quality and purity of the peptide product The duration of use Some dogs may experience mild injection site irritation or digestive upset