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doi: 10.1007/s00125-017-4489-7 [DOI] [PubMed] [Google Scholar] 50

(2024) reported that in TP53-mutant AML cells, cytarabine and idarubicin combination increase the levels of the p53 and p21 proteins, and upregulated the G2/M-phase cell-cycle checkpoints regulators cdc25c, p-CDK1, and Cyclin b in DTP cells, causing cell cycle arrest in G2/M phase and drug-resistance

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