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Cardiol Rev

During the process, the complement component activates the expression of C3a anaphylatoxin chemotactic receptor (C3AR1) and stimulates chemotaxis and granule enzyme release (GER), as well as superoxide anion production (SAP)

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however, in the initial stage of atherosclerosis, turbulent blood flow interrupts these connections, making them more permeable, or leaky, and allowing lipoproteins to penetrate into the space under the endothelial cells, known as the intima