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The putative mechanisms for the ameliorating effects of synbiotics on glycemic status principally mediated through amplifying SCFA production could be considered as four principal issues, namely, ameliorating glucose homeostasis, attenuating insulin resistance, amending gut integrity, and hindering proinflammatory signaling pathways ( Collectively, mounting data support the ameliorating impacts of either synbiotics or L-carnitine on obesity, lipid profile, or glycemic markers although distinctions in metabolic modifying agents, such as the participants ethnic group, genotype, health condition, dietary intake, physical activity, and baseline values of biological markers, along with formulation, dose, and supplementation length, might have resulted in diverse reports

Kinston Ferguson, John R

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Overall, these findings advocate for further exploration of natural product's potential in the innovative treatment strategy for obesity management, and leveraging their diverse mechanisms of action