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Following the invasion of surrounding tissues cancer cells can extravasate to the distant tissue parenchymas through the vascular system and form small nodules named micrometastases and further macroscopic tumors by colonization that secondary tissue (Hanahan and Weinberg 2011)

Kuwano T, Nakao S, Yamamoto H, Tsuneyoshi M, Yamamoto T, Kuwano M, et al

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Unlike other tyrosine kinases whose ligands are soluble proteins, the Ephs ligands are associated with the plasma membrane of expressing cells and are classified in two subclasses based on the type of membrane binding