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10.1152/physrev.00038.2010 207

Also, ghrelin-deficient mice (ghrl/) display normal levels of hypothalamic orexigenic and anorexigenic neuropeptides, normal spontaneous food intake patterns, and growth rates, and a normal hyperphagic response to fasting

The intestine has a high rate of energy utilization because the portal-drained viscera (PDV) (i.e., intestines, pancreas, spleen, and stomach), which contribute less than 5% of body weight (BW), account for approximately 30% of the whole-body energy expenditure and most of the energy that is utilized by the intestine 11,12
