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Exercise-induced IL-6, mainly from skeletal muscle, may inhibit pro-inflammatory cytokines like TNF and IL-1 and stimulate anti-inflammatory mediators

Secondary metabolic pathways may involve CYP1A1, CYP2D6, and CYP2E1, though their contributions are minor in comparison to CYP3A4

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Two recent studies re-evaluated the utility of prednisone/cyclophosphamide in the treatment of IPF but both studies failed to support its use [90,91]