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Description
Lactic acid can also be metabolized to butyrate, H 2 , and CO 2 by Clostridium spp
In addition, some exosomes improved the drug delivery efficiency by increasing the BBB membrane fluidity
Future perspective To date, impaired barrier permeability has been highlighted as the initiating factor for pathogenic infiltration into the intestinal mucosa and subsequent chronic inflammation due to exposure to PAMPs
Rigorous validation of metabolic markers (e.g., plasma PKM2, specific lipid species, and mitochondrial DNA) is essential for early diagnosis, disease activity monitoring, and treatment response prediction
