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Notably, normal rats exhibited a superior sagittal sinus pressure of 24 to 27 mmHg and superior mesenteric pressure and portal pressure of 35 mmHg similar to that of the inferior vena cava, though with values at least 1 mmHg higher in the portal vein

Additionally, excessive production of ROS can degrade and redistribute tight junction proteins, such as ZO-1 and occludin, via the Akt/ASK1/p38 MAPK signaling pathway
10.1007/s00702-004-0151-x 53 NissimI

10.1016/j.celrep.2023.112728