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Brooks previous studies have shown that nitisinone has no effect in OCA-1A, where theres no tyrosinase to stabilize, and OCA-3, where a different part of the melanin pathway is affected, so his team doesnt intend to pursue this drug for patients with those forms of albinism

Dysregulation of Lipid Homeostasis and Its Effects on the Protein Homeostasis System Failures in the lipid homeostasis system lead to changes in composition of the lipidome and formation of toxic lipid species (Figure 2A), which in turn can compromise the protein homeostasis system and generate toxic protein states (Figure 2B)

Thus, ascorbate transport will depend on the narrowness of the space that exists between endothelial cells

69,70 The mechanisms leading to statin-induced muscle damage are not entirely understood