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Indeed, measurements of noradrenaline (NA)-induced aerobic glycolysis by FRET nanosensors in individual astrocytes demonstrated an increased glucose utilisation, manifested as reduced NA-elevated free cytosolic glucose concentration, whereas the production of lactate by NA was unaltered

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This dysfunction might contribute to ALS neurodegeneration by impairing energy production and promoting cellular oxidative stress

Similarly, electrical and electromagnetic stimulation (e.g., transcranial magnetic therapy) have shown promise in preclinical models for enhancing RGC survival and axonal regeneration, though clinical translation remains nascent [235]
