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Beyond energy conversion, mitochondria are indispensable for a myriad of other cellular processes, including heme and steroid hormone synthesis, calcium ion (Ca 2+ ) buffering to regulate intracellular signaling, and the initiation of apoptosis via the mitochondrial pathway (36)

Concurrently, it degrades host Gpx4 through lysosome-mediated autophagy

For instance, targeting the upstream kinases that phosphorylate HDAC6, thereby modulating its activity, or manipulating its protein-protein interactions, could offer new ways to fine-tune HDAC6's functions specifically in oxidative stress-related pathologies

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