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Notably, miR-155 and miR-132 are among the dysregulated miRNAs implicated in key pathogenic pathways, including the NF-B signaling pathway, oxidative stress responses, and mitochondrial-mediated apoptosis, all of which contribute to testicular dysfunction and impaired spermatogenesis [14, 15]

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Methods: On January 5, 2023, Web of Science scanned documents with the terms Peyronie's disease Peyronie's disease treatment, Peyronie's disease management, Peyronie's disease surgery and Peyronie's disease injection from 1975 through 2023

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