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Using a cohort of n = 176 healthy elders from the Harvard Aging Brain Study (HABS), research indicates that global structural-functional connectivity coupling (global SFC) exhibits a negative correlation with cognitive performance, such that lower SFC is associated with worse cognitive function [70]

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age, severity of comorbid mental disorders (anxiety, depression), and the degree of autonomic nerve dysfunction will also affect the regulatory effect of VNS on the brain-gut axis ( 5 Study limitations The existing clinical trials are mostly single-center and small-sample studies, which have problems such as short follow-up periods, insufficient data on long-term efficacy and recurrence rates, and are centered around IBS-C patients