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The onset of these symptoms, generally 24 hours or more after the transdermal system has been removed, can be severe and may require medical intervention [see Warnings and Precautions (5.6)]

Advancing the needle deeper may expose pelvic viscera and vessels to risk of injury

As per the results for charantin, the relative bioavailability of the charantin in F1 when compared to that of F2 was found to be 0.68

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