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LA and/or ALC stimulated mitochondrial biogenesis, up-regulated the expression of PGC-1 and reduced the production of ROS during the 4-week pretreatment Since LA and ALC were withdrawn after a 4-week pretreatment, the question arose as to whether they actively enhanced the antioxidant defence systems for cells to be resistant to the ensuing 4-week rotenone challenge

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Cristina Cudalbu is supported by the Centre dImagerie BioMdicale (CIBM - UNIL/UNIGE/HUG/CHUV/EPFL - Switzerland) as well as by the Leenaards and Jeantet Foundations

It also contributes to antioxidant defense mechanisms within the body