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Receptor-binding studies have suggested that cagrilintide may have slightly altered receptor subtype selectivity compared to amylin for instance, it can activate all amylin receptor subtypes and also has some activity at the calcitonin receptor alone (CTR without a RAMP)

As a reminder, the 300 mg BID cohort in the PYR-210 clinical study, when specifically looking at patients that enrolled and were stable on standard-of-care, showed a 57% treatment effect

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