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EBioMedicine 14 , 5564 (2016)

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Peilin Xie, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Finally, prospects for ferroptosis-based interventions and future directions point to several promising treatment avenues, including regulating iron homeostasis via chelators or TfR1/FPN modulation, using antioxidants and lipid peroxidation inhibitors to target GPX4 and ACSL4, or employing gene therapies and stem cell/exosome approaches to combat ferroptosis