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But it will be recognized by the immune system in excess, activating the Toll-like receptor 4 (TLR 4) signaling pathway, and promoting the release of immune cells to release a large number of pro-inflammatory cytokines, such as TNF- and IL-6 (Qu et al., 2023)
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To support this, we compiled representative PK data for toxic TCMs listed in the Chinese Pharmacopoeia (ChP), as summarized in Table S1, Additional File 1
