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Expectedly, depletion of cystine or inhibition of the Xc- antiporter using synthetic small molecule inhibitors including erastin, sulfasalazine, sorafenib and even excess of glutamate triggered cystine depletion, decreased GSH level and reduced GPX4 activity, culminating in ferroptosis induction
Olney JW, Price MT, Salles KS, Labruyere J, Ryerson R, Mahan K, et al
Evaluation of hexadecyloxypropyl-9-R- 2-(phosphonomethoxy)propyl adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections
