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Elevated pro-inflammatory cytokines, such as interleukin-6, play a significant role in driving persistent inflammation in diabetic patients, leading to weakened immunity and impaired wound healing, which increases susceptibility to infections and related complications, such as diabetic foot ulcers [43]

In a cohort of pregnant women in Bangalore, India, with a high incidence of vitamin B-12 deficiency, we reported previously that women in the lowest tertile for plasma vitamin B-12 concentration during all 3 trimesters of pregnancy had significantly higher risk of IUGR that persisted after adjusting for maternal age, weight, education, and parity (12)

The ECS and Gut Microbiota The ECS regulates various physiological functions in the gastrointestinal tract, such as gut motility, secretion, and visceral sensation

Polymeric Nanoparticles Polymeric carriers, including chitosan and thiolated chitosan, PLGA, and layer-by- layer polyelectrolyte capsules, offer advantages that complement lipid systems