glp 1 agonists and sglt2 inhibitors vs. GLP-1 to Treat the Heart, the Kidneys the Brain Complementary Yet Distinct Roles of

For diabetic patients Patients with diabetes are often encouraged to lose weight

Comparison with other studies Overall, events of suicidal ideation and self-harm have not been found to be imbalanced in clinical trials between randomised groups.67 However, these trials were limited by their sample sizes and thus could not detect these rare but potentially important adverse events

Unlike GLP-1RAs, particularly dulaglutide (254), SGLT-2 inhibitors have not demonstrated cardiovascular benefits in primary prevention among individuals with multiple cardiovascular risk factors (261)

19-22 GLP-1 receptor agonists GLP-1 receptor agonists continue to grow in popularity for the treatment of T2DM due to their beneficial effects on glycemia and weight