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Diabetologia 2024, 67, 470482

If a patient is experiencing noticeable changes and its affecting their confidence or comfort, maintaining a healthy weight is a good foundational step, says Dr Karim

Notably, alanine substitution studies indicate that R 299 , W 306 , and E 373 of GLP-1R contribute to the binding affinity and potency of GLP-1

N Engl J Med 384(11):9891002 Davies M, Frch L, Jeppesen OK et al (2021) Semaglutide 24 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial
