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Tirzepatide activates two key hormones (GLP-1 and GIP) that help regulate appetite, insulin, and digestion

Physiology of peripheral and central GLP-1 signaling GLP-1 is a 30-amino acid peptide synthetized by enteroendocrine L cells of the small and large intestine, and also in the brain primarily by neurons of the nucleus tractus solitarius (NTS) within the caudal brainstem as a product of tissue-specific posttranslational cleavage of a larger precursor molecule preproglucagon (PPG)

doi: 10.1016/j.tem.2012.11.006, PMID: [DOI] [PubMed] [Google Scholar] 28

Semaglutide is a medication that acts like a hormone called glucagon-like peptide-1 (GLP-1)