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54 For example, AICAR treatment improves glucose tolerance and whole-body glucose disposal, and reduces hepatic glucose output, as well as plasma triglyceride and FFA levels

3 All doses effectively reduced HbA1c and fasting blood glucose, with the 80 mg and 120 mg doses showing the greatest weight loss compared to placebo

or 24 kg on 15 mg), compared to placebo (2.4%, 5 lb

Examining trial-specific data is beyond the current scope, but we can gain summative insights from meta-analyses of these RCTs
