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The medications activate potassium channels, which relax pericytes and allow previously constricted blood vessels to widen

Reason for caution: GLP-1 medications may alter pancreatic enzyme secretion and ductal flow, potentially triggering or worsening inflammation in vulnerable individuals

This is somewhat in contrast with the observed dose response for weight and glycemia reductions in the primary results of the trials contributing data, although in the T2D trial in particular there was a convergence of efficacy outcomes across the uppermost doses [25, 26]