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These agents are particularly useful as add-on therapies but may also suffer from incomplete CNS penetration and systemic side effects such as hypertension and insomnia due to their off-target activity

Negative controls were treated either with pre-immune serum instead of the primary antibody (Supplementary Figure 1A) or non-specific secondary antibody (goat anti-mouse IgG) (Supplementary Figure 1B)

Drug effects: The common element of the mechanism of action of the NPBC is the suppression of the synthesis of prostaglandins from peanut acid by inhibiting the enzyme cyclooxygenase

Any disruption caused by high concentrations of -EC supplementation could lead to adverse effects on cell viability (as observed in our study for the application of -EC standard at 10,000 M (Figs