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In AD, when the function of the BBB is impaired, neurotoxic proteins such as beta-amyloid peptide (A) and Tau protein cannot be effectively cleared and will accumulate in the cerebral blood vessels and brain parenchyma, accelerating neuronal damage and neurodegeneration (Lee et al., 2022

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In addition to IR and -cell dysfunction, obesity in T1DM is concomitantly associated with chronic inflammation, central adiposity and dyslipidemia [18]

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