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Description
174 G-202 (mipsagargin) contains a peptide (DEEEE) targeting PSMA linked to the small-molecule payload thapsigargin

Nevertheless, this strategy does not allow circumventing the intrinsic instability of the maleimide moiety, which is prone to hydrolysis during its introduction via amide-coupling, during purification and bioconjugation, limiting the overall functionalisation yield 19,20

Dagleish, M

Recommended intake 1 EMBO-CAPS 13 times daily, with or before meals
