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The four components of therapy that may be used in the treatment of HCV-related cryoglobulinemic vasculitis consist of (1) antiviral therapy for chronic HCV infection, (2) conventional immunosuppressive agents, (3) biologic therapies, specifically B-cell deleting monoclonal antibodies, such as rituximab, and (4) plasmapheresis.[16,17,27] In general, the approach to treatment depends on the severity of illness, which can range from mild-to-moderate (usually with only cutaneous involvement), to severe (with end-organ involvement), to life-threatening (typically rapidly progressing).[16] The goals of treatment are to provide prompt relief of active vasculitis and prevent further recurrences of cryoglobulinemic vasculitis

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