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Acknowledgements The authors thank Kristine M

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Dan Wool, NMD Arizona-licensed Naturopathic Physician and Gastroenterology Specialist Updated: November 11, 2025 Summary: What is "Leaky Gut" and Intestinal Permeability: "Leaky gut" refers to increased intestinal permeability where the one-cell-wide intestinal lining's tight junctions become damaged, allowing toxins, undigested food particles, and bacteria to enter bloodstream

Glucose is mainly converted into lactate (glycolysis), whereas glutamine is converted into glutamate, aspartate and alanine by undergoing partial oxidation in the TCA cycle to carbon dioxide, aspartate, alanine and lactate in a process called glutaminolysis (Reference Curi, Newsholme and Marzuca-Nassr3)
