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To mitigate the adverse effects of HHcy to wound healing, the supplementation of cofactors (B vitamins, folic acid) or other agents (IL-10) seems to be perspective in the treatment of several diseases, especially in type 2 diabetic patients, patients with various types of ulcers, fractures, or inflammatory bowel diseases

If IBD, EPI, SIBO, or parasites are driving the poor absorption, those conditions need their own treatment plan running alongside B12 therapy

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Tissue Distribution Patterns Delivery method influences where peptides accumulate: Injectable distribution : Direct systemic delivery allows more uniform distribution to peripheral tissues, potentially reaching target sites more effectively