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It is also a substrate for enzymes like sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate gene expression, DNA repair, and cellular stress responses

Dietary supplements: regulatory challenges and research resources
Influence of exercise intensity on systemic oxidative stress and antioxidant capacity

P., Russo, C., Antic, T., Vacante, M., Malaguarnera, M., Avitabile, T., Li, Volti G., and Galvano, F