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Description
Ethical principles of the study complied with the European Directive 010/63/E, the Law on Amendments to the Animal Protection Act (Official Gazette 37/13), the Animal Protection Act (Official Gazette 135/06), the Ordinance on the protection of animals used for scientific purposes (Official Gazette 55/13), Federation of European Laboratory Animal Science Associations (FELASA) recommendations, and the recommendations of the Ethics Committee of the School of Medicine, University of Zagreb
Objectives In this study, we validated the protective role of GYY4137 against OA pathological courses and elucidated its underlying regulatory mechanisms
The next important group of H 2 S prodrugs, some of which entered the clinical phase, includes H 2 S-releasing modifications of many clinically used drugs with the well-known ATB-346 which is a H 2 S-releasing derivative of naproxen [170,171] (Figure 12)
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