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A low mood that doesn't lift despite doing "all the right things." You start searching for answers, and somewhere between the medical websites and the social media posts, you land on B12 deficiency as a possible explanation

CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: further regulation by CD55 and CD59

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Second, the doses are small because the target is a high-affinity intracellular enzyme, not a receptor that needs saturating with milligrams of drug
