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Lipids, in particular cholesterol (Habchi et al., 2018) and gangliosides (Matsuzaki, 2020), can promote the primary nucleation of A, an event that at the normal A brain concentrations is otherwise likely to be rare (Habchi et al., 2018)
Astroglial atrophy in Alzheimers disease
One common trigger is blood loss, which can happen suddenly due to injury or gradually from conditions like heavy periods or ulcers
