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N-Acetyl Cysteine (NAC), a precursor of glutathione, is therefore often used instead and has been shown to successfully raise plasma glutathione levels, for example, in those with schizophrenia.[xi] Anthocyandins also recycle glutathione thus sparing it if supplemented together.[xii] NAC has plenty of evidence to support its use as a promoter of glutathione and mental health, thus reducing the brains oxidative stress

This activity may be driven by increased levels of brain-derived neurotrophic factor (BDNF) or through a more direct modulation of specific receptors that govern cognitive processes

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Hepcidin, a key regulator of systemic iron metabolism, is stimulated by the cytokine IL-6