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[DOI] [PubMed] [Google Scholar] 2.Sreepian A, Popruk S, Nutalai D, Phutthanu C, Sreepian PM
Beyond gastrointestinal comorbidities, IBS commonly coexists with conditions like pain syndromes, overactive bladder, migraines, visceral sensitivity, and psychiatric conditions
Thus, the hepatic cytochrome P-450 enzymes convert CP into hydroxy-cyclophosphamide, which is then metabolized to aldophosphamide
Resistance mechanisms, such as GPX4 upregulation, further complicate treatment
