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Furthermore, aged mice showed lower LPS- and zymosan-induced TNF- and IL-6 production in splenic macrophages compared with young mice (76)

Hypoxic regulation of osteoclast differentiation and bone resorption activity
In contrast, normal cells can synthesize methionine from homocysteine using methionine synthase, with cobalamin and 5-methyltetrahydrofolate serving as essential cofactors (2)
