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Treated mice showed significant reductions in body weight and white adipose tissue mass compared to untreated controls on the same high-fat diet

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It found that IV and oral administration of Fragment 176-191, when compared to placebo, led to no changes in: physical findings, laboratory parameters, glucose levels, glucose tolerance, insulin sensitivity, IGF-1 levels, or rates of adverse events (e.g

Yet another compound, Honokiol (HKL), has been shown to protect against doxorubicin-induced cardiotoxicity by activating SIRT3, which helps reduce ROS production, prevent mitochondrial fragmentation, and promote mitochondrial fusion 187