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[ref] Related article: NOS3 gene and nitric oxide Gut-brain axis: Nerves running from the brain to the intestines can move neurotransmitters and send signals in both directions
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To determine whether induced expression of IRF5 and IKK effectively reprogrammed macrophages from M2 to M1, researchers generated M2 macrophages by culturing bone marrow-derived macrophages (BMDMs) with IL-4
