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10.1073/pnas.1817885116 140

Biochim Et Biophys Acta Mol Cell Biology Lipids

Besides clinical applications, further toxicological investigations would also help to understand if the thiomethyl shunt acts only as a pathway for NAPQI detoxification and excretion, or if it can contribute to liver or renal toxicity in case of APAP overdose through the generation of intermediates with highly reactive sulfur-containing fragment as observed with environmental contaminants ( e.g

Samples were centrifuged at 4 C for 15 min, and 500 L of supernatant was transferred to a new tube and evaporated to dryness at room temperature (RT)