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In neutrophils, HRG binds to its receptor, CLEL1A, which maintains the quiescent status and low production of ROS to promote phagocytic activity, and in epithelial cells, the activation of CLEL1A inhibits the translocation of the cytokine HMGB1 to the extracellular matrix and promotes cell attachment by regulating E-cadherin levels

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This study provided additional information on the potential effect of ALCAR on disease progression and survival and adds evidence to justify the use of ALCAR in ALS subjects

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