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Successful signal detection in FIH studies depends on adequate collection of data coupled to a systematic analysis of the data, a determination of the strength of a potential signal and an understanding of the quantitative limitations of typical study designs

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Cardiovascular outcomes, long-term efficacy and safety In people with T2D and established cardiovascular disease, the international guidelines for T2D recommend the use of GLP-1 RA or sodium glucose co-transporters 2 inhibitors (SGLT-2i) as first-line treatment (independent of HbA1c), based on multiple trials demonstrating their cardio-renal benefits [109]