Methylation cycle hypothesis
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Non c' bisogno di ulteriori forme energetiche, per cui la beta ossidazione deve essere inibita: anzi, al contrario, il fegato inizia il processo di lipo sintesi a partire dalle fonti energetiche disponibili
10.1371/journal.pone.0092842 [DOI] [PMC free article] [PubMed] [Google Scholar] 55.Cuturic M, Abramson RK, Moran RR, Hardin JW, Hall AV
Complementary medicines (herbal and nutritional products) in the treatment of Attention Deficit Hyperactivity Disorder (ADHD): a systematic review of the evidence
The data also suggest that upregulating BCKDH activity by treatment with, for example BT2, an inhibitor of BDK (Neinast et al., 2018), may attenuate accumulation of BCKAs in MSUD
