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UVA, UVB, and UVC radiation trigger DNA damage and promote the production of H 2 O 2 , the most frequently found ROS from UV radiation, damaging cellular proteins, lipids, and DNA [20,58]

Basal blood hematology and biochemistry were performed at the screening Visit 1 on all subjects

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Its key feature lies in the competitive utilization of the same substrate by iNOS (also known as Nos2) and Arg1: the former generates NO and is closely associated with pro-inflammatory effects, whereas the latter produces ornithine and polyamines and participates in tissue repair and immune regulation ( Under classical pro-inflammatory stimulation (such as LPS/IFN-), iNOS expression is upregulated and catalyzes the conversion of Arg into NO and citrulline