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Injected solution of Fraction A from 4 th chromatography step and purified on 5 th chromatography step, detection: UV = 254 nm

requires medical monitoring Diabetes: Monitor blood sugar carefully with any B3 supplementation Gout or high uric acid: Niacin may worsen these conditions Peptic ulcers: Niacin may aggravate symptoms Pregnancy/lactation: Stick to RDA levels

Chin J Physiol 42:171179 Johns RA, Moscicki JC, DiFazio CA et al (1992) Nitric oxide synthase inhibitor dose-dependently and reversibly reduces the threshold for halothane anesthesia

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