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Any of these sites can contribute to this reduction in bioavailability, and the overall process is known as first-pass elimination

doi: 10.3389/fphar.2023.1303207 Received 27 September 2023 Accepted 31 October 2023 Published 04 December 2023 Volume 14 - 2023 Edited by Francisco Lopez-Munoz, Camilo Jos Cela University, Spain Reviewed by Christopher Freet, The Pennsylvania State University, United States Marilia Gag Pereira, Federal University of Alfenas, Brazil Updates Copyright 2023 Bates, Getsy, Coffee, Baby, MacFarlane, Hsieh, Knauss, Bubier, Mueller and Lewis

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Taghaddosinejad FF, Ghazanfari-Nasrabad E, Eizadi-Mood M, Hajihosseini N, Mehrpour M